PKRRATING OPTIONS

3B). R526 through the loop involving αJ and αI anchors the C-terminal portion of the activation loop by forming a salt bridge with E458 at the base of αEF. Q459 stabilizes the HRD motif by a hydrogen bond to the main chain carbonyl of R413. The suggestion on the activation segment is stabilized by a hydrogen bond between Y454 and E480 from αfil